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Effect of adrenalectomy on lithium distribution in various tissues of rats was studied. Rats were divided into three groups; namely, untreated, Li treated, and Li treated after adrenalectomy was done on 3rd dat prior to lithium treatment. Animals were killed following lithium treatment, and tissues including blood were taken immediately and digested and Li and Na concentrations were measured by atomic absorption spectroscopy. Effect of adrenalectomy on lithium distribution in various tissues was abserved, e. g. : brain skeletal muscle, bone, liver, renal cortex, cardiac muscle as well as plasma and erythrocyte. Correlations of Li concentrations were analyzed for each tissues. Results were smmarized as follows: 1. Adrenalectomy resulted an increase of lithium concentrations of various tissues in rats. 2. Erythrocyte to plasma ratio of lithium concentration was elevated in adrenalectomized rats, and it was considered that Li passed fairly well into cell under the adrenalectomy. 3. Adrenalectomy promoted the lithium retention in some tissues, especially bone, skeletal muscle and brain. 4. No correlation between tissues Li and Na was observed every tissues examined. 5. Lithium retention mechanism and pattern of distribution in some tissues of adrenalectomized rats were discussed.
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